Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer (TRIPL) This is a research study exploring how combining radiation therapy with dual immune checkpoint inhibition can improve outcomes for patients with locally advanced non-small cell lung cancer (NSCLC) . This study focuses on patients whose cancer cannot be surgically removed but has not yet spread beyond the chest. It tests whether adding inhibitors of PD-1 (Programmed Death-1) and...

A Randomized Phase III Trial INcorporating Pathologic Complete ReSponse in Participants with Early StaGe Non Small Cell Lung Cancer to Optimize ImmunotHerapy in the AdjuvanT Setting (INSIGHT) The INSIGHT study is a Phase III, randomized research study investigating how to optimize immunotherapy for patients with early-stage non-small cell lung cancer (NSCLC) after surgery, also known as the adjuvant setting. This study focuses on patients who have undergone surgical removal of their lung...

Randomized Phase III Trial of mFOLFIRINOX /- Nivolumab vs. FOLFOX /- Nivolumab for First-Line Treatment of Metastatic HER2-Negative Gastroesophageal Adenocarcinoma This randomized Phase III research study is comparing two chemotherapy-based treatment regimens—mFOLFIRINOX ± nivolumab and FOLFOX ± nivolumab—as first-line therapy for patients with metastatic HER2-negative gastroesophageal adenocarcinoma (a type of cancer that starts in the stomach or the junction where the esophagus meets the...