NCI-2023-00768

An open label, randomized study of neoadjuvant nivolumab and chemotherapy, with or without sub-ablative stereotactic body radiation therapy, for resectable stage IIA to IIIB non-small cell lung cancer

This study is about testing different treatments for non-small cell lung cancer (NSCLC) that can be removed by surgery (resectable). The study involves giving patients an immunotherapy drug called nivolumab along with chemotherapy before they have surgery. Some patients will also receive a type of radiation therapy called stereotactic body radiation therapy (SBRT) before surgery, while others won't. The study is  randomized and open-label, which means everyone knows which treatment they're getting. The goal is to see if adding nivolumab and SBRT to chemotherapy before surgery can improve outcomes for patients with resectable no- small cell lung cancer (NSCLC)

EGFR: Epidermal Growth Factor Receptor (EGFR) is on the surface of cells and helps them grow and divide. In cancer, EGFR is like a switch that gets stuck in the "on" position, making cells grow and divide too much.

NSCLC: A type of lung cancer with non small cells that grow too much and can spread to other parts of the body

randomized: Patients are randomly assigned to one of two groups. It's like flipping a coin to decide who gets which treatment

open-label: Patients know which treatments are being given to them

resectable: Some patients have a tumor that is “resectable,” which means that it is able to be removed with surgery.

immunotherapy: The immune system helps fight cancer by sending the body's defense (immune) system to kill the cancer cells. Immunotherapy drugs target cancer cells to prevent them from multiplying and growing.

stereotactic body radiation: a treatment method delivers strong and precise doses of radiation to cancerous tumors, aiming to get rid of cancer cells while sparing nearby healthy tissue from harm.

For more information about the trial, click the link below:

https://clinicaltrials.gov/ct2/show/NCT05500092

Clinical Trial Site: Einstein

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