NCI-2024-04895

A Phase III Randomized Clinical Trial of Proton Craniospinal Irradiation Versus Involved-Field Radiotherapy for Patients with Breast Cancer or Non-Small Cell Lung Cancer Leptomeningeal Metastasis (Radiate-LM)

This Phase 3 research study (Radiate-LM) is comparing two types of radiation treatments for people with breast cancer or non-small cell lung cancer (NSCLC) that has spread to the leptomeninges — the thin layers of tissue covering the brain and spinal cord. This condition, called leptomeningeal metastasis, is serious and difficult to treat. The study is testing whether proton craniospinal irradiation (proton CSI) — a precise form of radiation that treats the entire brain and spine while reducing damage to healthy tissue — is more effective than involved-field radiotherapy (IFRT), which only targets specific areas affected by cancer. Researchers aim to find out which approach better controls the disease, improves symptoms, and increases survival while minimizing side effects.

Phase 3: A phase 3 clinical trial is a large-scale study designed to assess the effectiveness and safety of a new medical treatment or approach compared to a standard treatment

For more information about the trial, click the link below:

https://clinicaltrials.gov/ct2/show/NCT06500481

Clinical Trial Site: Einstein

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